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Efficacy of Immunosuppressive Therapy for IgA Nephropathy With Stage 3 or 4 CKD

RecruitingPhase 3Ages 18 Years - anyAllAir Force Military Medical University, China
NCT05510323 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this clinical trial is to evaluate the long-term efficacy and safety of low-dose oral corticosteroids combined with cyclophosphamide therapy and low-dose corticosteroids monotherapy, on a background of maximal RAS inhibitor therapy, for IgA nephropathy with stage 3 or 4 chronic kidney disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Biopsy-proven IgA nephropathy; * Proteinuria ≥1.0g/day while receiving maximum tolerated dose of RAS blockade; * Estimated glomerular filtration rate 15-60 ml/min/1.73/m2. Exclusion Criteria: * Indication or contraindication for immunosuppressive therapy with corticosteroids * Use of corticosteroids and other immunosuppressive drugs within the last 1 year * Current unstable kidney function for other reasons * Under 18 years old * Patients with secondary IgAN * Patients who are unlikely to comply with the study protocol in the view of the treating physician
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What it tests

  • Prednisolone
  • Prednisolone plus Cyclophosphamide
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Where

1 site
AFMMU
Xi'an, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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