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Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors

Recruitingn/aAges 18 Years - 55 YearsMaleUniversity Medical Center Groningen
NCT05514223 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The cause of infertility can be due to a female factor or a male factor. In case of a male factor, it is often due to poor semen quality. However, the cause of poor quality is often unknown. In previous research, infertility problems in men were related to chemical processes in metabolism causing the formation of free radicals. Free radicals are physiological by-products of our body mechanisms. Free radicals are very reactive and can therefore react with a lot of molecules of cells within our body and cause damage. A balance between free radicals, which are also needed for physiological processes in the body, and antioxidants, which defuses the reactive free radicals, is most desirable. However, as stated in literature, there are a lot of factors that can influence extra free radical production, which causes overloading of the system, resulting in damage on cellular level. Free radicals

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📋 Eligibility rules (as published)
Inclusion Criteria: * Males of couples visiting the CRM at the UMCG between 18-55 years old. * Planned semen-analysis as standard care. Exclusion Criteria: * Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone suppletion and/or anabolic steroids * Males who are azoospermic * Males who have an abnormal SA due to genetic causes. * Semen analysis with round cells \>2x106 /ml (as marker for infection) * Males who currently use antibiotics
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What it tests

  • Biomaterial collection for observational purpose
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Where

1 site
University Medical Centre Groningen
Groningen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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