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Investigational Scan (68Ga-FAPI-46 PET/CT) for Imaging of Cancer-Associated Fibroblasts for Localized Pancreatic Ductal Adenocarcinoma

RecruitingPhase 2Ages 18 Years - anyAllMayo Clinic
NCT05518903 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This phase II trial tests whether 68Ga-FAPI-46 positron emission tomography (PET)/computed tomography (CT) scan works to image cancer-associated fibroblasts (CAFs) in patients with pancreatic ductal adenocarcinoma (PDA) that has not spread to other parts of the body (localized). CAFs are a type of connective tissue cell that are found within or near cancerous tissue. Many CAFs express a protein called fibroblast activation protein (FAP) that are not found on healthy cells in large amounts. 68Ga-FAPI-46 is a radioactive chemical compound designed to circulate through the body and attach itself to FAP on PDA cells. A PET/CT scan is then used to detect the location of FAP lesions. PET scan is a procedure in which a small amount of radioactive glucose (sugar) is injected into a vein, and a scanner is used to make detailed, computerized pictures of areas inside the body where the glucose is t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults \> 18 years (yrs.) with treatment-naive biopsy-proven PDA or with findings diagnostic for PDA on baseline imaging (CT, MRI, or PET) * Localized disease expected to undergo surgical resection following neoadjuvant therapy (NAT) * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Ability to provide informed consent Exclusion Criteria: * Hypersensitivity to any excipients in 68Ga-FAPI-46 * Require emergency surgery * Non-PDA histology on biopsy * Histopathologically proven metastatic PDA * Pregnant or lactating women
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What it tests

  • Computed Tomography
  • Gallium Ga 68 FAPi-46
  • Positron Emission Tomography
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Where

1 site
Mayo Clinic in Rochester
Rochester, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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