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Clinical Trial of YH32367 in Patients With HER2 Positive Locally Advanced or Metastatic Solid Tumor

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllYuhan Corporation
NCT05523947 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This first-in-human study will be counducted to evaluate the safety, tolerability, pharmacokinetics (PK) and anti-tumor activity of YH32367 in Patients with HER2-Positive Locally Advanced or Metastatic Solid Tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: \[Dose Escalation Part\] * Pathologically confirmed HER2-positive * Mandatory provision of tumor tissue sample \[Dose Expansion Part\] * Patients who have at least one measurable lesion * Mandatory provision of tumor tissue sample 1. Cohort 1: Pathologically confirmed HER2-positive biliary tract cancer 2. Cohort 2: Pathologically confirmed HER2-positive metastatic solid tumor malignancy other than breast and gastric or gastroesophageal junction adenocarcinoma and biliary tract cancer Exclusion Criteria: * Uncontrolled central nervous system (CNS) metastases * Spinal cord compression * Carcinomatous meningitis * Acute coronary syndromes * Heart failure * Interstitial lung disease (ILD) * Pneumonitis * History of a second primary cancer * Human immunodeficiency virus (HIV) * Active chronic hepatitis B * Hepatitis C * Systemic steroid therapy * Autoimmune disease
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What it tests

  • YH32367
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Where

19 sites
Dana Farber Cancer Institute
Boston, United States
Vanderbilt Ingram Cancer Center
Nashville, United States
Southern Oncology Clinical Research Unit
Adelaide, Australia
Austin Health
Melbourne, Australia
Breast Cancer Research Centre - WA
Perth, Australia
Blacktown Hospital
Sydney, Australia
CHA Bundang Medical Center
Seongnam-si, South Korea
Catholic University of Korea St. Vincent's Hospital
Suwon, South Korea

…and 11 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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