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Cytokine Filtration in Lung Transplantation: A Swedish National Study (GLUSorb)

RecruitingNAAges 18 Years - 80 YearsAllLund University Hospital
NCT05526950 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lung transplantation (LTx) remains the gold standard for treating patients with irreversible end-stage pulmonary disease. Of the major organs transplanted, survival in LTx recipients remains the lowest (mean 5 years). Despite improvements, primary graft dysfunction (PGD), as defined by respiratory insufficiency and edema up to 72 hours post LTx, remains the leading cause of early mortality and contributes to the development of chronic lung allograft dysfunction (CLAD) which is the leading cause of late mortality. PGD develops within the first 72 hours after LTx. The development of CLAD increases quickly with cumulative incidence of 40-80 % within the first 3-5 years. There is a general lack of efficient treatments for PGD and CLAD. Prevention of PGD is therefore of crucial importance and has a direct impact on survival. The present study is a randomized controlled study which aims to co

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📋 Eligibility rules (as published)
Inclusion Criteria: • Eligibility to undergo double lung transplantation at either trial site Exclusion Criteria: 1. Age \<18 years 2. Previous organ transplantation 3. Presence of any conditions at the time of surgery that require immunosuppressive therapy. Immunosuppressive therapy is defined as: 1. Cyclosporine, Tacrolimus, Everolimus, or Sirolimus, minimum 1 month of treatment prior to transplantation and active treatment at the time of transplantation. 2. Any form of antibody-based treatment that is known for having an immunomodulatory effect taken up to 1 week before transplantation. 4. Non-consent
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What it tests

  • Device: CytoSorb
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Where

1 site
Sandra Lindstedt
Lund, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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