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Replicative Stress in Hair Follicle Stem Cells and Pathogeny of Hidradenitis Suppurativa

RecruitingNAAges 18 Years - 99 YearsAllAssistance Publique - Hôpitaux de Paris
NCT05531747 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hidradenitis Suppurativa is a recurrent chronic inflammatory follicular occlusive disease affecting hair follicles. HS is notoriously difficult and challenging to treat with a high morbidity impact and could be classified as an unmet medical need with no efficient therapeutic options. Objective: Investigators previously showed that Outer Root Sheath Cells (ORS) isolated from hair follicle of HS patients (HS-ORS) have a pro-inflammatory phenotype and secrete spontaneously IP-10 and RANTES. To identify the mechanisms involved in the pro-inflammatory phenotype of HS-ORS, investigators performed a transcriptomic analysis in healthy and HS patients. This revealed: (i) an IFN signature, (i) a dysregulation of genes involved in cell proliferation and differentiation, and (iii) an upregulation of DNA damage response and cell cycle G2/M checkpoint pathways in HS-ORS. These findings support the

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients referred to the consultation of dermatology of Henri Mondor Hospital * Diagnosis of Hidradenitis Suppurativa * Age\> 18 y.o. * Affiliation to a social security system Exclusion Criteria: * Patient under tutorship or curatorship * Breastfeeding or pregnant women * Refusal to sign the consent letter * Patients benefiting from State Medical Aid
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What it tests

  • Skin biopsy
  • Blood sample
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Where

1 site
Assistance Publique Hôpitaux de Paris - CHU Henri Mondor
Créteil, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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