Percutaneous Coronary RevascularizatiOn VERsus Coronary-Artery Bypass Grafting for Multivessel Disease in Patients With Left Ventricular Dysfunction (PROVERB)

Inclusion Criteria: * Age ≥18 years * Left ventricle ejection fraction ≤35% measured by echocardiography, cardiac magnetic resonance imaging ventriculogram or gated Single Photon Emission Computed Tomography ventriculogram * Multivessel disease suitable for revascularization: * Three vessel disease * Two vessel disease involving left main or proximal left anterior descending artery * Clinical and anatomic eligibility for both percutaneous coronary intervention (PCI) and Coronary artery bypass grafting (CABG) as agreed to by the local Heart Team (interventionalist determines PCI appropriateness and eligibility; cardiac surgeon determines surgical appropriateness and eligibility) * Ability to sign informed consent and comply with all study procedures, including follow-up for at least two years * Affiliation to health insurance Exclusion Criteria: * Prior: * PCI of any coronary artery lesions within 6 months prior to randomization * CABG at any time prior to randomization * Ongoing cardiogenic shock at the time of coronary angiogram (SBP\< 90 mmHg with clinical signs of low output or patients requiring inotropic agents) * Contra indication for PCI or CABG determined by the heart team * Indication for another cardiac surgery (i.e. valvular surgery, aortic repair…) if CABG is performed * ST elevation myocardial infarction \< 30 days * Non-cardiac illness with a life expectancy of less than 24 months * Current participation in other investigational drug or device studies * Women who are pregnant or nursing * Females of childbearing potential without effective method of birth control * Patients who are under tutorship or curatorship * Patient on AME (state medical aid)