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The ED-AWARENESS-2 Trial

RecruitingNAAges 18 Years - anyAllWashington University School of Medicine
NCT05534243 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria. The study design is a pragmatic, multicenter, stepped wedge cluster randomized trial, enrolling at five sites over a 3-year period, divided into six time periods of six months. Prior to the study, each site will be randomized to their position within the design. One site will cross to the intervention period (i.e. succinylcholine as default neuromuscular blocker) every six months from the 2nd to 6th time period. Cluster order will be determined by computer-based randomization. To begin, each site will be exposed to control conditions; by the end of the study, each site will be exposed to intervention conditions. Patients in the control phase will receive usual care, and this phase will be entirely observational

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Mechanical ventilation via an endotracheal tube 2. Age ≥ 18 years 3. Treatment with a neuromuscular blocker (for endotracheal intubation or during the post-intubation phase of care) Exclusion Criteria: 1. Acute or chronic neurologic injury with deficit that prevents assessment of AWP (i.e. stroke, intracranial hemorrhage, traumatic brain injury, cardiac arrest, severe dementia) 2. Death before extubation 3. Transfer to another hospital from the ED
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What it tests

  • Standard neuromuscular blocker practices
  • Education
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Where

4 sites
Roy J. and Lucille A. Carver College of Medicine
Iowa City, United States
Hennepin Healthcare
Minneapolis, United States
Cooper University Hospital/Cooper Medical School of Rowan University
Camden, United States
University of Washington School of Medicine
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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