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Muscle Recovery After Critical Illness

Recruitingn/aAges 18 Years - anyMaleEsther Dupont-Versteegden
NCT05537298 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness: 1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments 2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors 3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission

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📋 Eligibility rules (as published)
Inclusion Criteria: * adult (\>18 y/o) * admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU Exclusion Criteria: * patients who were not ambulatory prior to ICU admission * experienced \>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason * patients not expected to survive \~6months after admission * acute or chronic neurologic condition * acute or chronic orthopedic condition preventing strength/functional testing * morbid obesity \>50 kg/m2 due to distortion of muscle ultrasonography
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What it tests

  • Not listed
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Where

3 sites
University of Alabama at Birmingham
Birmingham, United States
University of Kentucky
Lexington, United States
Oklahoma Medical Research Foundation
Oklahoma City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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