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Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT05542056 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Newly prescribed thiazide or thiazide-like diuretic * ≥ 18 years of age * Informed Consent as documented by signature Exclusion Criteria: * Intake of thiazide or thiazide-like diuretic in the preceding month * Hyponatremia (plasma sodium \<135 mmol/L) at baseline * Acute infectious / inflammatory disease (CRP ≥ 20 mg/L \[1, 11\]) * Symptomatic urinary tract infection * Chronic treatment with NSAID and / or NSAID intake 48 hours prior to urine sampling at visit 1 and 2 (intake of acetylsalicylic acid will be no exclusion criteria) * End of life care, no informed consent or inability to follow the procedures of the study, e.g., due to language barriers, psychological disorders, dementia
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What it tests

  • Data and biosample collection
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Where

3 sites
Hospital Universitario de Móstoles
Móstoles, Spain
University Hospital Basel, Endocrinology, Diabetes and Metabolism
Basel, Switzerland
Kantonsspital Baselland
Liestal, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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