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Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients With Exudative AMD (SINE)

Recruitingn/aAges 18 Years - anyAllFondation Ophtalmologique Adolphe de Rothschild
NCT05547633 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis. Some patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis. The investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Patient followed and treated for at least 2 years for bilateral neovascular form of age-related macular degeneration (AMD) * At least one eye treated with ≥ 6 intravitreal injections during the year preceding preinclusion * Express consent to participate in the study * Affiliated with or beneficiary of a social security plan Exclusion Criteria: * Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curatorship). * Severe myopia (\> 6 diopters) * Patient already being treated for acute or chronic sinusitis * History of central serous chorioretinopathy or diffuse retinal epitheliopathy
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What it tests

  • sinusitis screening consultation
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Where

1 site
Hôpital Fondation A. de Rothschild
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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