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A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

RecruitingNAAges 18 Years - anyAllMayo Clinic
NCT05547698 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Bilateral Lung Transplantation (LTx) recipients. * Mean pulmonary artery pressure \< or = 35 mmHg. * Eligible for off-pump or VA ECMO based on the judgement of the attending surgeon. Exclusion Criteria: * Single lung transplant * Multiorgan transplant. * Donor after cardiac death (DCD). * Re-transplant. * Intention to use prophylactic post-operative ECMO. * Previous major lung surgery. Video-assisted thoracoscopic surgery (VATS) and wedge resection are not an exclusion criterion. * Previous pleurodesis. * Preoperative ECMO and/or mechanical ventilation.
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What it tests

  • Off-pump lung transplantation
  • Venoarterial ECMO lung transplantation
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Where

10 sites
Cedar's Sinai
Los Angeles, United States
Emory University
Atlanta, United States
University Of Louisville
Louisville, United States
Johns Hopkins
Baltimore, United States
Mayo Clinic Rochester
Rochester, United States
Ohio State University
Columbus, United States
Temple University
Philadelphia, United States
UT Southwestern
Dallas, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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