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Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients

Recruitingn/aAges 65 Years - anyAllShanghai Ninth People's Hospital Affiliated to Sh…
NCT05555693 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postoperative cognitive dysfunction (POCD) refers to the difficulties of orientation, cognition, communication, memory and abstract thinking of patients after anesthesia and surgery. And/or accompanied by the decline of the ability in social activities, such as the change of personality, social ability of language and behavior, cognitive function and life skills. POCD is a common complication of central nervous system in elderly patients after operation, with an early incidence of about 21% and a long-term incidence of about 35% . According to the current research on Alzheimer's disease (AD) and POCD in the elderly, it has been found that they have similar pathological basis and some homologous related genes. Altogether, POCD is closely related to molecular pathway neuropsychiatric diseases (such as dementia, depression and Alzheimer's disease). Researchers have come up with various hypo

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📋 Eligibility rules (as published)
Inclusion Criteria: * 65 years or older . * Complete the operation in our hospital * ASA classification I-II level * Agree to participate in this research and agree to sign an informed consent form Exclusion Criteria: * History of preoperative psychosis and psychotropic drug use * The subject is diagnosed with AD; * Abnormal preoperative mental scale assessment * Have a history of emergency rescue during the perioperative period * metal implants * Postoperative immobilization patients
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What it tests

  • Collecting clinical data, EGG，Brain Metabolomic Characteristics(with Magnetic Resonance Spectroscopy), blood gas data and blood sample
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Where

1 site
Shanghai 9Th Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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