The Effect of SAAE on Vascular Endothelial Function in PA Patients

Inclusion Criteria: * (1)Aged 18-75 years, males and females; * (2)Blood pressure ≥ 140/90 mmHg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging \>130/80 mmHg throughout the day or averaging \>135/85 mmHg during the day; * (3)Primary aldosteronism was diagnosed in accordance with the 2016 international society of Endocrinology clinical guidelines after strict drug elution; * (4)Contraindications to spironolactone-free administration; * (5)No surgical intention or surgical contraindications, and willing to accept drug treatment or percutaneous superselective adrenal artery embolization; * (6)The anatomy of adrenal arteriography is suitable for selective adrenal artery embolization. Exclusion Criteria: * (1)Secondary hypertension of other causes; * (2)Pregnant women or those who have a fertility plan in the next year; * (3)Glomerular filtration rate EGFR \< 45 ml/min/1.73m\^2; * (4)History of severe contrast allergy; * (5)Hyperkalemia; * (6)Patients with other serious organic diseases or life expectancy \< 12 months can not tolerate the treatment of super selective adrenal artery embolizatio; * (7)The diameter of adrenal space occupying lesions was more than 2 cm; * (8)A history of myocardial infarction, syncope, cerebral hemorrhage or cerebral infarction within 3 months before the informed consent; * (9)The results of this study will be affected during the period when patients are enrolled or will participate in other clinical studies.