🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy

Recruitingn/aAges 18 Years - anyAllAshkan Eftekhari
NCT05564689 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Cardiac resynchronization therapy (CRT) is an effective therapeutic strategy in patients with symptomatic heart failure (HF) patients with LVEF of ≤35% and left bundle branch block (LBBB). However, approximately one-third of CRT-recipients do not improve after therapy (non-responders), despite meeting the required criteria. Previous studies have documented that the positive respons to CRT is related to the delayed electrical activation of the left ventricle in patients with LBBB. It has also been illustrated that non-ischemic CRT-candidates with LBBB demonstrate lower regional myocardial blood flow and metabolism in the septum. Additionally, it has been suggested that LBBB can lead to impaired coronary blood flow in the left anterior descending artery (LAD). This observation is based on an echocardiography-based study, that showed that the percentage of diastolic flow duration (%DD) in

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 * QRS ≥ 150 ms before implantation * Heart failure because of dilated cardiomypathy * Sinus rhythm * Stable medical therapy * LBBB * CRT device Exclusion Criteria: * eGFR \< 30 ml/min * Severe valvular heart disease * Permanent atrial fibrillation or atrial flutter * Prior PCI or CABG * Prior myocardial infarction * Heart failure due to ischemic heart disease * Other type of device (pacemaker, ICD) * Not able to give informed consent * Does not understand Danish
💊

What it tests

  • Intracoronary flow and pressure
📍

Where

1 site
Aalborg Universityhospital
Aalborg, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy