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A Pilot Study for Optimizing Meropenem Administration in the ICU

RecruitingNAAges 18 Years - anyAllOslo University Hospital
NCT05578586 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Can antibiotic drugs be administered faster and make acceptable serum concentrations if we give short but multiple infusions compared to long and fewer infusions? In this study we will compare giving meropenem 1 gram 6 times daily in 15 minutes infusions to the recommended 2 gram 3 times daily in 3 hours infusions. In patients in the intensive care unit, the need for intravenous access is of essence. If 6 short infusions results in the same serum concentrations as 3 long infusions, we will increase intravenous access from 15 to 22.5 hours daily.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients ≥ 18 years admitted to the ICU at Oslo University Hospital, Rikshospitalet and 2. who shall be treated with meropenem because of proven or suspected serious infection and 3. who give their written informed consent either directly or through next of kin Exclusion Criteria: Patients 1. with known hypersensistivity to betalactam antibiotics or 2. who use of valproat or 3. who are pregnant or 4. the lack of consent.
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What it tests

  • Meropenem 1000 mg
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Where

1 site
Oslo University Hospital
Oslo, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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