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Thyroid Function and Structure in Klinefelter Syndrome

Recruitingn/aAges 1 Year - 80 YearsMaleUniversity of Roma La Sapienza
NCT05581147 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis; * Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging; * Availability of concurrent clinical data. Exclusion Criteria: * Presence of other known genetic conditions or chromosomal abnormalities; * Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests; * History of previous surgery or radiotherapy on the thyroid or pituitary glands; * Current or previous T therapy (for the pre-pubertal and pubertal groups).
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What it tests

  • Not listed
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Where

1 site
'Sapienza' University of Rome
Roma, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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