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Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue

RecruitingPhase 2Ages 34 Years - 80 YearsAllVA Office of Research and Development
NCT05584124 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive transcranial magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue and other clinical characteristics related to mood and cognition before and after participants receive rTMS.

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📋 Eligibility rules (as published)
Inclusion Criteria: * More than 6 months post-stroke * Clinically present fatigue Exclusion Criteria: * Contraindications to magnetic resonance imaging (MRI)/transcranial magnetic stimulation (TMS)/repetitive transcranial magnetic stimulation (rTMS), e.g., implanted metal within the head, history of seizures * Inability to follow simple three-step instructions * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe traumatic brain injury (TBI) * Pregnancy * Strokes within stimulation sites * Pregnancy * Severe hypertension (resting systolic blood pressure (SBP) \> 200, DBP \> 120)
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What it tests

  • High frequency repetitive transcranial magnetic stimulation
  • Sham repetitive transcranial magnetic stimulation
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Where

2 sites
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, United States
Ralph H. Johnson VA Medical Center
Charleston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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