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Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome. * Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: 1. Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow. 2. Affiliation to social security (AME excluded) 3. Patient with one of the circulatory failures described below: * septic shock * cardiogenic shock * post-resuscitation syndrome * Cardiogenic shock: * Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND * Cardiac index \<2 L/min/m2 or left ventricular ejection fraction (LVEF)\<35%, AND * Lactate \>2.0 mmol/l * Post-resuscitation syndrome: * Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli\> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND * Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND * Lactate \>2.0 mmol/l * Septic shock: * Suspected or proven bacterial infection * Need for a vasopressor support to maintain mean arterial pressure\>65 mmHg * Lactate \>2.0 mmol/l * Cardiac index\>3L/min/m2 or LVEF\>40% Exclusion Criteria: 1. Onset of shock (catecholamine infusion) \>12 hours prior to inclusion 2. Age \<18 year old 3. Pregnancy
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What it tests

  • Not listed
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Where

1 site
Hôpital Européen Georges Pompidou
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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