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Decolonization to Reduce After-Surgery Events of Surgical Site Infection

RecruitingPhase 4Ages 18 Years - anyAllUniversity of California, Irvine
NCT05586776 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older * Recent open (not solely laparoscopic) surgery involving an abdominal incision within the past 14 days. For cesarean section, recruitment restricted to BMI ≥ 40. * Able to communicate regularly by phone * Able to bathe, shower or have this task performed by a caregiver Exclusion Criteria: * Transfer to an acute care hospital * Discharged to receive end-of-life hospice measures * Discharged more than 14 days after surgery * Allergic to mupirocin and/or chlorhexidine * Active infection at enrollment\* \*Refers to 1. Infections requiring systemic antibacterial agents, so viral illness (e.g., COVID, flu) is not an exclusion. 2. Topical antibacterial agents do not count toward exclusion (e.g., topical products for acne) 3. Prophylactic antibacterial agents do not count toward exclusion * Surgical incision not closed at discharge
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What it tests

  • 4% Chlorhexidine Gluconate
  • 2% Mupirocin
  • Soap Without Antiseptic Properties (Placebo)
  • Placebo Nasal Ointment
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Where

4 sites
Hoag Memorial Hospital Presbyterian
Newport Beach, United States
University of California, Irvine Medical Center
Orange, United States
University of California, Davis Medical Center
Sacramento, United States
University of California, San Francisco Medical Center
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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