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Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion

Recruitingn/aAges 18 Years - anyAllPeking University Third Hospital
NCT05589207 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of inferior vena cava (IVC) vascular wall invasion in renal cell carcinoma (RCC) with tumor thrombus invading vascular wall.The main questions it aims to answer are: * To establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations. * To determine what impact does different vascular wall layer invasion make on the long-term prognosis in RCC with IVC tumor thrombus; * To determine which layer invasion according to pathological examination make sense to clinical treatment (can significantly affect prognosis); Participants with IVC vascular wall invasion/ non-invasion are divided into experimental group (invaded grou

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ≥18 years of age; * Accepted abdominal ultrasonography, contrast-induced ultrasonography, enhanced CT and MRI before the surgery; * Diagnosis of primary renal cell carcinoma with tumor thrombus before and during the surgery; * Received radical nephrectomy and at least one kind of thrombectomy (including IVC incision only, IVC partial resection, IVC diagonal resection, and IVC segmental resection) * Can tolerate the surgery; * Eastern Cooperative Oncology Group Performance Status Scale (ECOG-PS) 0\~2; * No previous history of malignant tumor; * Willing to return for required follow-up visits Exclusion Criteria: * Failed to receive standard nephrectomy for any reason; * Attached other addition operations in the surgery; * Received neoadjuvant treatment before the surgery; * Experience any other conditions that may affect the curative effect (e.g. active tuberculosis, autoimmune disease, or oral glucocorticoids treatment); * Experience serious consequences or death due to anesthesia accident during operation;
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What it tests

  • Vascular wall invaded
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Where

1 site
Peking University Third Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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