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Early Severe Illness TrAnslational BioLogy InformaticS in Humans

Recruitingn/aAges 18 Years - anyAllLondon Health Sciences Centre Research Institute …
NCT05591924 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation. These syndromic presentations often meet the diagnostic criteria of sepsis and/or the acute respiratory distress syndrome (ARDS), the two most common syndromes encountered in the intensive care unit (ICU). Although critical illness syndromes, such as sepsis and ARDS, have separate clinical definitions, they often overlap clinically and share several common injury mechanisms. Moreover, there are no specific therapies for critically ill patients, and as a consequence, approximately 1 in 4 patients admitted to the ICU will not survive. The purpose of this observational study is to identify early patient biologic factors that are present at the time of ICU admission that will he

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years old * ≤48h since ICU admission * ICU admission within 72h of presentation to the emergency department (ER) * Clinical critical illness suspected on the basis of any one of the following: 1. Altered mental status (GCS\<15) 2. Cardiovascular collapse (presence of any: Heart rate \>90, systolic blood pressure \<90, presence of vasopressors, lactate \>2.0) 3. Respiratory collapse (presence of any: respiratory rate \>20, PaCO₂ \<32 mm Hg, supplemental oxygen, invasive or non-invasive ventilation) 4. Suspected severe infection (presence of any: temperature \>38°C or \<36°C, white blood cell (WBC) count \>12,000/mm³ or \<4,000/mm³, presence of 1 or more antibiotics at the time of ICU admission) Exclusion Criteria: * Age \<18 years old * \>72h since ICU admission * Admission to ICU in patients \>72h after the presentation to the ER * No evidence of critical illness (ICU admission due to bed-spacing)
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What it tests

  • Phelebotomy
  • Broncheoalveolar Lavage
  • Tracheal Aspirate
  • Rectal Swab
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Where

1 site
Aleks Leligdowicz
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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