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Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery

Recruitingn/aAges 65 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT05595954 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass. Exclusion Criteria: * Surgery requiring moderate (28-31.9ºC) or deep (\<28ºC) hypothermic circulatory arrest; * Heart and/or lung transplantation; * Urgent (within 24 hours) and emergency surgery; * Inability to follow procedures or insufficient knowledge in English, German or French; * Inability to give consent. Participants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.
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What it tests

  • Preoperative data collection
  • Intraoperative NIRS
  • Intraoperative TCD
  • Intraoperative invasive MAP
  • Postoperative NIRS
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Where

4 sites
Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel
Basel, Switzerland
Inselspital, Bern University Hospital
Bern, Switzerland
Cambridge University Hospitals and Brain Physics Lab
Cambridge, United Kingdom
Royal Papworth Hospital, Department of Anaesthesia and Intensive Care
Cambridge, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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