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Role of Intrapulmonary Lymph Nodes in Patients With NSCLC and Visceral Pleural Invasion

Recruitingn/aAges 18 Years - anyAllLuzerner Kantonsspital
NCT05596578 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Lung cancer is the leading cause of cancer related death worldwide. More than 80% of all lung tumors are Non-Small Cell Lung Cancers (NSCLC). Lymph node staging has a prognostic value and is crucial to establish the optimal treatment strategy in individual patients. It remains unknown whether dissecting the intrapulmonary lymph nodes (stations 13 and 14) is necessary for accurate staging and prognostication. Although suggested by several guidelines, these peripheral lymph nodes are not routinely examined in clinical routine for several reasons. Moreover, the prognostic significance of the visceral pleural invasion is controversial. Some studies showed a negative impact on OS and DFS in patients with histologic proved visceral pleura invasion. The mechanism to explain this negative effect is not fully understood. Given that the visceral pleura is very rich in lymphatic vessel

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📋 Eligibility rules (as published)
Inclusion Criteria: * Anatomical resection for NSCLC \<3 cm (lobectomy, bilobectomy, segmentectomy) * Samples from the intrapulmonary stations 12, 13, and 14 lymph nodes * Resection of lymphnodes station 10 and 11 during hilar separation. * R0 resection Exclusion Criteria: * Prior or synchronous lung cancer * pN2 * Pneumonectomy * R1/R2 resection * M1 * Neoadjuvant treatment
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What it tests

  • Not listed
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Where

1 site
Kantonsspital Luzern
Lucerne, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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