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Phenotyping Heterogeneity and Regionality of the Aorta

Recruitingn/aAges 18 Years - anyAllHeinrich-Heine University, Duesseldorf
NCT05603520 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort

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📋 Eligibility rules (as published)
1. apparently healthy volunteers Inclusion Criteria: • Healthy volunteers Exclusion Criteria: * \< 18 years * Active Medication * Cardiovascular Disease * MRI not possible 2. Patients with Aortic Stenosis Inclusion Criteria: • Patients suffering from 3rd drgree Aortic Stenosis Exclusion Criteria: * \< 18 years * MRI not possible 3. Patients with Aortic Aneurysms Inclusion Criteria: • Patients suffering from Aortic Aneurysms Exclusion Criteria: * \< 18 years * MRI not possible
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What it tests

  • Collection of Clinical Data
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Where

1 site
Christine Quast
Düsseldorf, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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