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โ† Trials
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Concomitant Hybrid Versus Catheter Ablation for Atrial Fibrillation With Hypertrophic Cardiomyopathy

RecruitingNAAges 18 Years - anyAllChina National Center for Cardiovascular Diseases
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the rhythm control effect in hypertrophic non-obstructive patients with non-paroxysmal atrial fibrillation by either concomitant catheter endocardial and thoracoscopic epicardial ablation or catheter ablation alone. The study aims to see if concomitant hybrid ablation can more effectively achieve rhythm control effect than catheter ablation alone in non-paroxysmal atrial fibrillation patients with hypertrophic cardiomyopathy.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patients' age is โ‰ฅ18 y 2. Clinically diagnosed hypertrophic cardiomyopathy (any left ventricular wall segment thickness โ‰ฅ15 mm in genetical negative (or unknown genetical status) patients or โ‰ฅ13mm in genetical positive ones-as measured by any imaging technique (echocardiography, cardiac magnetic resonance imaging or computed tomography)-that is not explained solely by loading conditions) 3. Non-obstructed left ventricular outflow obstruction with peak gradients \<30mmHg 4. Concomitant with persistent atrial fibrillation (7 days\<sustained episode lasting\<3 years) with drug-refractory symptoms. 5. Be able to understand the contents of the trial, and provide written informed consent to participate in this investigation. Exclusion Criteria: 1. Patients with left atrial size \>60 mm (2-dimensional echocardiography, parasternal long-axis view) 2. Contraindicated to systemic anticoagulation 3. Left ventricular ejection fraction โ‰ค40% 4. Concomitant with left atrium or left atrial appendage emboli 5. Concomitant with a coronary or valvular disease that indicates intervention 6. Ischaemic stroke within 2 months 7. Previous ablation history 8. Uncontrolled hyper/hypothyroidism 9. End-staged kidney failure 10. Concomitantly involved in other trials 11. Pregnant or breastfeeding, or women of childbearing age not using a reliable contraceptive method 12. Concomitant with bacteremia or at an active phase of infection 13. Anatomically not suitable for thoracoscopic surgery(history of chest surgery or radiotherapy, etc.) 14. Unwilling or unable to comply with all peri-ablation and follow-up requirements
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What it tests

  • hybrid ablation
  • catheter ablation
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Where

1 site
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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