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Study of the Metabolism in the Lymphatic Niche of CLL

Recruitingn/aAges 18 Years - 90 YearsAllCentre Hospitalier Universitaire de Nice
NCT05610228 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic lymphoid leukemia (CLL) is the most common adult leukemia that is characterized by a malignant monoclonal accumulation of tumoral and quiescent B cells in the peripheral blood. In advanced stages of the disease (Binet stage C), this population invades the bone marrow (BM) and proliferate into the lymphoid organs that results in widespread adenopathy. Richter's transformation is a most aggressive serious complication of CLL (transformation of the disease into an aggressive lymphoma) detected based on TEP/CT (Positron Emission Tomography/ computerized tomography) that shows highly derived glucose consumption by cancer cells. Clinical data from CLL patients with disease acutisation showed hypermetabolic lymphadenopathy with high standardized uptake value (SUV) whereas there is low grade tracer uptake into BM. We supposed that the tumor microenvironment of the lymphatic niche promote

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients for whom the diagnosis of CLL has been established cytologically and phenotypically (Matutes score) * Patients over 18 years old * Patients who have signed the non-objection form * Untreated patients Exclusion Criteria: * Patient with a solid cancer that is progressive or in remission for less than 3 years * HIV positive patients * Patients with chronic active hepatitis B or C * History of allogeneic transplant
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What it tests

  • NO intervention
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Where

1 site
Nice University Hospital
Nice, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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