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Precision Medicine in the Depression Treatment

Recruitingn/aAges 18 Years - 65 YearsAllCopenhagen University Hospital, Rigshospitalet
NCT05616559 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The BrainDrugs-D study uses multimodal neuroimaging combined with self-report measures, clinical and molecular markers to identify clinically relevant predictors that can identify subtypes of major depressive disorder (MDD) and, in a naturalistic setting, predict treatment response to standard antidepressive treatment. The cohorts are followed in nationwide health registries.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 65 years * Fulfilment of International Classification of Diseases version 10 diagnostic criteria for a primary depressive episode (i.e., not secondary to known organic or other psychiatric disorder). * Referral to a treatment package for single-episode depression. Exclusion Criteria: * Psychosis or psychotic symptoms * History of severe head trauma * Somatic disease associated with morphological brain changes (e.g., brain tumour) * Insufficient Danish language skills to complete questionnaires and cognitive testing Additional exclusion criteria for Cohort II: * Severe somatic disease * Contraindications for MRI (e.g., metal implants, claustrophobia or back problems) Additional exclusion criteria for Cohort III: * Severe somatic disease * Contraindications for MRI * Exposure to radioactivity \>10 mSv within the last year * Pregnancy or breastfeeding * Use of psychotropic drugs
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What it tests

  • Treatment Package for First-Episode Depression
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Where

1 site
Neurobiology Research Unit, Rigshospitalet
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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