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Quantifying Systemic Immunosuppression to Personalize Cancer Therapy

Recruitingn/aAges 18 Years - 90 YearsAllFondazione IRCCS Istituto Nazionale dei Tumori, M…
NCT05621837 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The Serpentine (Stratify cancER PatiENTs by ImmuNosupprEssion) project, represents the most consistent effort so far attempted to translate MDSC into clinical practise by producing an off-the-shelf compliant assay for quantifying these cells in peripheral blood.

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📋 Eligibility rules (as published)
Inclusion Criteria * Histologically documented diagnosis of metastatic/locally advanced melanoma, hormone-refractory breast cancer, RCC and UC, SCCHN, SCC or NSCLC, stage III resectable NSCLC will also be included * Will and ability to comply with the protocol * Willingness and ability to provide an adequate archival Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample available for exploratory biomarker analysis * Age from 18 to 90 years at the time of recruitment * ECOG Performance Status \<= 2 * Understanding and signature of the informed consent * Consenting to participate to the socio-economical-psychological survey Exclusion Criteria * Known history of HIV infection * Serious neurological or psychiatric disorders * Pregnancy or lactation * Inability or unwillingness of participant to give written informed consent * Inability or unwillingness to be regularly followed up at the same center
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What it tests

  • MDSC quantification
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Where

1 site
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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