Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection

Inclusion Criteria: 1. living in Jakarta, Surabaya, and Yogyakarta City for at least 6 months permanently; 2. apparently healthy; 3. male and female, age 12-17 years old; 4. overweight or obese (BMI-for-age z-score \>+1SD); 5. have completed at least two dosages of COVID-19 vaccine, the vaccine must be CoronaVac® (Sinovac); 6. minimal 6 months post vaccinated prior to recruitments. 7. parents willing to sign the informed consent and adolescents give informed assent; 8. Must have an active health insurance, for instance BPJS or similar health insurance. Exclusion Criteria: 1. having a history of COVID-19 infection within the last month confirmed by PCR or antigen from health care facilities or independent laboratory; 2. having a history of chronic and non-communicable diseases, congenital diseases, and disabilities; 3. reported current diagnosed as suspected active Tuberculosis (primary lung TB, miliary TB, bleeding cough bone TB, meningitis TB); 4. having a history of gastrointestinal or malabsorption disorder (such as celiac disease and inflammatory bowel disease) within the last three months or during the study; 5. taking antibiotics during 2 weeks before the start of the study (adolescents will be included after 3 weeks of last antibiotic intake); 6. taking other medications or having diseases that may influence the immune response - i.e. immune deficiencies, immunosuppressants medications, blood transfusion or other blood products; 7. taking insulin and/or anti-dyslipidemia medication; 8. being pregnant and/or breastfeeding.