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Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

RecruitingPhase 3Ages 18 Years - anyFemaleUniversity Hospital, Toulouse
NCT05625724 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin prophylaxis during pregnancy may be effective in the prevention of preterm preeclampsia and other perinatal adverse outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Nulliparous women aged 18 years or more * Pregnancy following ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), oocyte donation or intrauterine insemination with sperm donor * Singleton pregnancy * Evolutive pregnancy between 9 and 14 weeks of gestation * Women affiliated to a French Social Security Insurance or equivalent social protection * Written informed consent Exclusion Criteria: * Major fetal abnormality * Regular treatment with aspirin (including antiphospholipid syndrome) * Aspirin contraindications (allergy, von Willebrand disease, peptic ulceration, hemophilia) * Women protected by law. * Women included in another interventional study.
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What it tests

  • Aspirin
  • Placebo
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Where

21 sites
CHU Angers
Angers, France
CHU Bordeaux
Bordeaux, France
CHU Clermont-Ferrand
Clermont-Ferrand, France
CHU Dijon-Bourgogne
Dijon, France
CHU Lille
Lille, France
HCL - Groupement Hospitalier Est, Hôpital Femme Mère Enfant
Lyon, France
AP-HM Hôpital de la Conception
Marseille, France
AP-HM Hôpital Nord
Marseille, France

…and 13 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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