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Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)

RecruitingNAAges 7 Years - 99 YearsAllChulalongkorn University
NCT05631405 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test) * And still in febrile phase (Body temp\>37.5 C) * Shock : Sys\<90mmHg or Narrow PP (\<20mmHg) orTachycardia (pulse\>100/min) with Hematocrit decreased ≥20 % * Fluid accumulation and respiratory distress * Severe bleeding * Severe organ involvement Exclusion Criteria: * Severe dengue\> 24 hrs * Dengue without warning signs * Pregnancy * Patient who receieved any steroid within 1 week
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What it tests

  • Dexamethasone
  • Placebo
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Where

2 sites
Chulalongkorn University
Bangkok, Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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