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Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients

RecruitingPhase 4Ages 65 Years - 90 YearsAllYongtao Sun
NCT05635877 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation. 2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 65 years; 2. ASA: ⅰ-ⅳ; 3. Modified frailty index (mFI) ≥ 0.21; 4. Patients undergoing non-cardiac surgery. Exclusion Criteria: 1. Refuse to participate; 2. Expected hospital stay \<3 days; 3. Preoperative β-blocker therapy; 4. History of myocardial infarction or coronary artery disease; 5. Preoperative bradycardia (heart rate \[HR\] \< 50 bpm) or arrhythmia; 6. Significant cardiac insufficiency (i.e., pulmonary artery pressure \>18 mm Hg, cardiac index ≤ 2.2 L/min/m 2); 7. Severe valvular heart disease; 8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease); 9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia); 10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause. \-
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What it tests

  • Esmolol
  • Placebo Comparator: Placebo Comparator:normal saline(0.9%)
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Where

1 site
Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
Jinan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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