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Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Geneva
NCT05641441 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated. Additionally, the investigators will invite patients with vestibular Schwannoma to fill out questionnaires to assess their quality of life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 years or above * Patients with unilateral VS treated either with SRS or MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study * Patients willing to take part in the study and give their informed consent Exclusion Criteria: * Previous surgical or radiation therapy for VS (including SRS) * Patients diagnosed with neurofibromatosis type II * Preexisting profound hearing loss, with a pure tone average (PTA) \>90 and word recognition score (WRS) \<10%, upon initial assessment * Previous middle ear surgery of the affected ear * Concurrent treatment with other experimental drugs
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What it tests

  • Stereotactic radiosurgery
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Where

1 site
Service d'ORL et Chirurge cervico-faciale, Hopitaux Universitaires de Genève
Geneva, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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