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Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

RecruitingNAAges 18 Years - anyAllMedical University of Graz
NCT05642156 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written consent of the participant after being informed * At least 18 years of age * End stage kidney disease patient undergoing hemodialysis * Dry weight stable for a minimum of one month * Interdialytic weight gain of \>2 liters in the short interdialytic interval Exclusion Criteria: * No informed consent was obtained * Patients with a pacemaker or implanted medical device that prevents compliance with study regulations * Patients treated with hemodiafiltration * Patients treated with medium cut-off membranes (Theranova, Baxter) * Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \> 6.0 mmol/L, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments. * Women of childbearing age not using contraception
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What it tests

  • isolated Ultrafiltration (iso-UF)
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Where

1 site
Medical University of Graz
Graz, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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