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Feasibility of Reducing Respiratory Drive Using the Through-flow System

RecruitingNAAges 18 Years - anyAllUniversity Health Network, Toronto
NCT05642832 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.

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📋 Eligibility rules (as published)
Inclusion Criteria: * PaO2/FiO2 less than or equal to 300 at time of screening * Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation * Bilateral airspace opacities on chest radiograph or chest CT scan Exclusion Criteria: * Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal/gastric varices) * Intubation for traumatic brain injury or stroke * Intracranial hypertension (suspected or diagnosed by medical team) * Anticipated liberation from mechanical ventilation within 24 hours
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What it tests

  • Throughflow titration phase
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Where

1 site
University Health Network
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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