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โ† Trials
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Dietary Approach to Mild-to-moderate Psoriasis

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Palermo
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In plain words

What the trial is, and whether it could suit you

Psoriasis is a systemic chronic inflammatory immune-mediated disease whose etiopathogenetic mechanisms involve genetic predisposition, and immunological and environmental factors. Its prevalence is about 3% in adults, and it is characterized by well-demarcated, erythematous plaques, covered by silvery-white scales, in elbows, knees, trunk, and scalp. However, psoriasis is far from being considered just a dermatologic condition because the cytokine's cascade, which lays behind its inflammatory and immune-mediated pathogenesis, can determine multiple systemic manifestations. In addition, several patients with psoriasis often complains of gastrointestinal (GI) symptoms. Therefore, authors focused their attention over the gut-skin axis and its possible pathogenetic and immunoregulatory role in psoriasis (i.e., altered gut barrier, increased blood concentration of gut microbiota-derived metab

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria of psoriasis patients * age \>18 and \<65 years; * no systemic therapy for psoriasis for at least 3 months before inclusion in the study; * negativity of anti-deamidated gliadin protein (anti-DGP) immunoglobulins (Ig) class A (IgA) and immunoglobulins (Ig)G, anti-tissue transglutaminase (anti-tTG) class IgA and IgG, and Endomysium antibodies (EmA); * absence of WA (negative prick-test and/or specific serum immunoglobulins (Ig)E assay for wheat, gluten, and gliadin). Exclusion criteria of psoriasis patients age \<18 and \>65 years; * severe chronic plaque-type psoriasis (based on BSA); * self-exclusion of gluten/wheat from the diet and refusal to reintroduce it, for diagnostic purposes, before entering the study; * pregnancy; * alcohol and/or drug abuse; * Helicobacter pylori and other bacterial and/or parasitic infections; * diagnosis of chronic inflammatory bowel disease and other organic pathology affecting the digestive system (e.g., severe liver disease), nervous system diseases, major psychiatric disorders, immunological deficits, and impairments that limit physical activity; * diagnosis of cancer * treatment with steroids and/or immunological therapies; * patients undergoing chemotherapy and/or radiotherapy.
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What it tests

  • Open wheat challenge
  • Placebo challenge
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Where

3 sites
Dermatology Department of the University Hospital 'P. Giaccone' of Palermo, Italy,
Palermo, Italy
Internal Medicine Department of the University Hospital of Palermo
Palermo, Italy
Internal Medicine Division of the "Cervello-Villa Sofia" Hospital
Palermo, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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