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PErsonalized TReatment for Endometrial Carcinoma

RecruitingNAAges 18 Years - 100 YearsFemaleUniversity of Helsinki
NCT05655260 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the efficacy of adjuvant therapies in women with stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma. Specifically, the invesigators want to compare: * Chemotherapy vs. chemoradiotherapy in p53 abn subtype and nonendometrioid carcinomas. * Vaginal brachytherapy vs. whole pelvic radiotherapy in the MMR-D molecular subgroup. * Vaginal brachytherapy vs. whole pelvic radiotherapy in the NSMP molecular subgroup.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 to 100 years * WHO performance status 0 to 2 * Stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma Exclusion Criteria: * Age \<18 years or \>100 years * WHO performance status \>2 * Uterine sarcoma * A history of malignancy within 5 years * Previous pelvic radiotherapy * An interval of \>30 days between surgery and start of chemotherapy or \>8 weeks between surgery and start of radiotherapy (longer intervals may be permitted with investigator´s approval)
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What it tests

  • Comparison of chemotherapy vs. chemoradiotherapy
  • Comparison of VBT vs. WPRT
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Where

1 site
Helsinki University Hospital
Helsinki, Finland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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