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Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

Recruitingn/aAges 1 Month - 99 YearsAllNational Institute of Allergy and Infectious Dise…
NCT05656365 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood. Symptoms can include swelling of the glands in the throat, mouth ulcers, and tonsillitis. Removal of the tonsils can stop the periodic flareups. But researchers do not know how PFAPA develops. In this natural history study, researchers will collect specimens and data from people with PFAPA to see what they might have in common. Objective: To collect blood and other specimens from people with PFAPA to learn more about the illness. Eligibility: People aged 1 month or older with symptoms of PFAPA or another tonsil disorder. Design: Participants will be screened. Their medical records will be reviewed. Researchers will ask about a family history of PFAPA. The following specimens may be collected: Blood. Blood will be drawn either from a

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: Participants must meet all the following inclusion criteria to be eligible for this study: 1. Aged \>=1 month. To be seen at the NIH CC, participants must be \>=3 years of age. 2. Diagnosed with PFAPA or another tonsil disorder, or has symptoms consistent with these conditions, as determined by the investigator. 3. Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 years). 4. Willing to allow specimens and data to be stored for future research. 5. Willing to allow genetic testing on their biospecimens. EXCLUSION CRITERIA: An individual who has any condition that, in the judgment of the investigator, may put them at undue risk or make them unsuitable for participation in the study will be excluded.
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What it tests

  • Not listed
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Where

3 sites
Children's National Medical Center
Washington D.C., United States
Indiana University School of Medicine
Indianapolis, United States
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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