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Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis

Recruitingn/aAges 18 Years - anyAllUniversity of Dublin, Trinity College
NCT05663008 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS. Early diagnosis in individuals improves clinical care and facilitates timely entry into clinical trials. However, current methods for diagnosis are primarily clinical, and to date, no cost-effective biomarkers have been developed. Our objective is to identify a robust non-invasive neurophysiological-based system that can be used both as a biomarker of disease onset, and a measurement of progression using quantitative EEG and surface EMG (bipolar and high-density). The investigators postulate that analysing the joint recordings of EEG and EMG (bipolar or high-density) can give measures that better distinguish healthy people and ALS patient subgroups and that the findings can be developed as biomarkers of

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📋 Eligibility rules (as published)
Inclusion Criteria: Healthy Volunteers: * age and gender-matched to patient groups * the intact physical ability to take part in the experiment. Patients: * Diagnosis of ALS, PLS, PMA, SMA, Polio or MS * capable of providing informed consent. Exclusion Criteria: Healthy Controls: * History of neuromuscular * neurological or active psychiatric disease disease * history of reaction or allergy to recording environments, equipment and the recording gels. Patients: * the presence of active psychiatric disease * any medical condition associated with severe neuropathy (e.g. poorly controlled diabetes). * History of reaction or allergy to recording environments, equipment and the recording gels.
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What it tests

  • 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)
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Where

1 site
Academic Unit of Neurology, Trinity College Dublin, The University of Dublin
Dublin, Ireland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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