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Neurobiological Markers of Treatment Response for Anxiety and OCD

Recruitingn/aAges 16 Years - anyAllHaukeland University Hospital
NCT05663489 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided. International guidelines recommend cognitive behavioral therapy (CBT) as the first-line treatment, and research has shown that CBT can be delivered over a concentrated period of time. The Bergen 4-Day Treatment (B4DT) is an exposure-based treatment which is delivered over four consecutive days. B4DT has been shown to induce rapid and long-lasting remission in around 70% of patients. This provides a platform for studying psychological and neurobiological changes associated with treatment response and non-response. The present study will investigate longitudinal changes in psychological measures and DNA methylation in patients who receive the B4DT, as well as a subset will also undergo multimodal brain imaging.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed with obsessive-compulsive disorder, panic disorder or social anxiety disorder using DSM-5 criteria * Referred to National Clinic for 4-Day Treatment, Haukeland University Hospital, Bergen, Norway * Consented to participate in the "Kvalitetsregister for konsentrerte behandlingsformat" Exclusion Criteria: * Suicidal, ongoing mania, primary eating disorder, intellectual disability, ongoing psychosis, ongoing substance abuse For MRI substudy: Inclusion Criteria: \- For the healthy controls, no previous or current psychiatric disorders as detected by the Mini International Neuropsychiatric Interview (MINI) Exclusion Criteria: \- MRI incompatibility (e.g. pregnancy, metal implants)
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What it tests

  • Bergen 4-Day Treatment (B4DT)
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Where

1 site
Bergen Center for Brain Plasticity
Bergen, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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