🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

RecruitingNAAges any - anyAllUniversity Hospital, Ghent
NCT05670301 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation The goal of this prospective, observational study is to describe the longitudinal evolution of blood cytokine profiles in patients with presumed or confirmed diseases of systemic inflammation The main questions it aims to answer are: * What are the differences and similarities in blood cytokines between different patients and groups presenting symptoms of systemic inflammatory conditions? * How is the cytokine profile of individual patients evolving over time and what is the effect of different therapeutics? * Is cytokine profiling a valuable tool to diagnose and follow-up on patients with systemic inflammatory conditions? Participants will be asked to give an additional blood volume for research purposes

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: An individual who meets any of the following criteria can be eligible for participation in this study: 1. Child or adult 2. Written informed consent 3. Suspected or confirmed disease with systemic inflammation (acute, chronic and/or recurrent), these include: 1. Autoinflammatory diseases (AID), including among others: systemic onset juvenile idiopathic arthritis (sJIA), familial mediterranean fever (FMF), mevalonate kinase deficiency (Hyper IgD syndrome), TNF receptor-associated periodic syndrome (TRAPS), familial Cold Autoinflammatory Syndrome (CAPS), type 1 interferonopathies,… 2. Autoimmune diseases (AI), including among others: systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), rheumatoid arthritis (RA),… 3. Hyperinflammatory diseases, including among others: hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndrome (MAS), infection-related cytokine storm (e.g. in the setting of COVID-19) 4. Other unidentified or not yet identified systemic inflammatory conditions 4. Blood sample for diagnostic purposes is planned and possibility to acquire additional blood volume Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Confirmed localized infection and/or good response to first-line antibiotic treatment 2. Confirmed malignancy Besides the above mentioned patients, volunteers that meet the requirements as a healthy individual are eligible for inclusion as controls.
💊

What it tests

  • cytokine and lipidomic profiling
📍

Where

7 sites
UZ Antwerpen
Antwerp, Belgium
ZNA
Antwerp, Belgium
UZ Brussel
Brussels, Belgium
Ghent University Hospital
Ghent, Belgium
UGent
Ghent, Belgium
Jessa Hospital
Hasselt, Belgium
UHasselt
Hasselt, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy