rTMS for Depressive, Positive and Negative Symptoms, and Physiological Indices of Schizophrenia Patients

Inclusion Criteria: * Age ≥ 20 years * Able to give informed consent * Diagnosed with schizophrenia or schizoaffective disorder according to DSM-5 * Has a score ≥ 7 on Calgary depression scale for schizophrenia * The principal psychotropic agents are not changed within one month of the first session of rTMS Exclusion Criteria: * DSM-5 defined substance use disorder (excluding tobacco) in the past 3 months * Have clinically relevant cognitive impairment (e.g., delirium, intellectual disability or MMSE \< 15) * With electronic and/or magnetic implants (e.g. pacemaker, implantable cardioverter defibrillator \[ICD\], cerebral shunts, cochlear implant, etc.) * With metallic or mechanic fragments (e.g., screws, plates, stents, clips, etc.) * Pregnant, or has a pregnancy plan within 3 months * With any known or history of neurological conditions including cerebral vascular accidents, epilepsy (or epileptiform waves detected by EEG prior to the first session of rTMS), brain tumor or space occupying lesion * Received rTMS or iTBS treatment within 3 months * Has a clinically significant abnormality on the screening examination that might affect safety, study participation, or confound interpretation of study results