TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer

Inclusion Criteria: * Willing and able to sign informed consent * Subject is able and willing to complete all procedure and follow-up visits indicated in the protocol * Absence of urinary retention * Prostate volume: ≥ 18 and ≤ 100 cc, measured by transrectal ultrasound * Serum creatinine levels \<2 ng/dl and GFR \> 45 * Serum PSA levels \< 20 ng/ml * Multiparametric prostate MRI with piRADS scores 3-5 * Prostate volume: ≥ 18 and ≤ 100 cc, measured by MRI * Presence of Intermediate risk prostate cancer with a volume that is less than 1/3 of the gland volume by MRI evaluation Exclusion Criteria: * Post-void residual (PVR): \> 250 mL or \> 50% of voided volume * Previous prostate cancer intervention (Radiation therapy, brachytherapy, prostate cryoablation * Major neurological conditions such as Alzheimer's, Parkinson, Multiple sclerosis, ALS, spinal cord injury * Evidence of neurogenic bladder determined by urodynamics studies * Presence of Indwelling Foley catheter or on active regime of clean intermittent catheterization (CIC) in the prior 30 days * Active urinary tract infection determined by urinary cultures * SHIM score \<14 * IPSS score \>23 * Acute prostatitis * Macroscopic hematuria without a known contributing factor * History of colorectal carcinoma with anterior perineal resection of rectum * History of pelvic radiation therapy or radical pelvic surgery * History of bladder neck contracture and/or urethral strictures within the 5 years prior to the informed consent date * Bladder stones * Medical contraindication for undergoing TPFLA surgery (eg, infection, coagulopathy, significant cardiac or other medical risk factors for surgery) * Diagnosed or suspected bleeding or coagulopathic disorder such as hemophilia, ITP, TTP * Medical contraindication to being subjected to local anesthesia