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Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

RecruitingPhase 1Ages 18 Years - anyAllUniversity Hospital, Lille
NCT05699005 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock. An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age of 18 and older, * supported by peripheral VA-ECMO * for cardiogenic shock * Life expentency \>90 days * Central venous line available ScVO2 measurement Exclusion Criteria: * Pregnancy, * Lack of health insurance, * Opposition to blood transfusion, * Known congenital hemoglobin disease or disorder, * Metabolic alcaloosis with pH\>7.8, * eCPR, * Legally incapacitated adults
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What it tests

  • Packed Red Blood Cells (PRBCs)
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Where

4 sites
Service d'Anesthésie-Réanimation CCV Hôpital Cardiologique Centre Hospitalier et Universitaire de Lille
Lille, France
CHU Amiens
Amiens, France
CHU Dijon
Dijon, France
Centre de Réanimation, Hôpital Salengro, CHU Lille
Lille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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