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Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Recruitingn/aAges 18 Years - anyAllFondation Ophtalmologique Adolphe de Rothschild
NCT05701852 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

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📋 Eligibility rules (as published)
Inclusion Criteria: * For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin. * For controls: matched to a case on age (±5 years) and sex Exclusion Criteria: * Neurodegenerative or inflammatory neurological pathology * Clinical depressive syndrome * High doses of opioid treatment (greater than 100 mg/day of morphine equivalent) * Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks * Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
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What it tests

  • reward learning task
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Where

1 site
Hôpital Fondation Adolphe de Rothschild
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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