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Assessing the Presence of CT-DNA in Lymphoma Associated HLH

Recruitingn/aAges 18 Years - anyAllNottingham University Hospitals NHS Trust
NCT05702502 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Haemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening blood disease which causes severe inflammation with symptoms similar to severe sepsis. It is hard to diagnose. The most common cause of HLH in adults is lymphoma (blood cancer). Outcomes for adults with HLH and cancer are serious, and most die after days or weeks because they have been diagnosed or treated too late. It is likely that many cases where patients died of HLH with no underlying cause actually had cancer. Recently it has been found that patients with certain types of lymphoma have DNA which comes directly from their cancer (circulating tumour DNAอพ ctDNA). Aggressive lymphomas release a lot of ctDNA which can be detected in the blood of patients. This study will look for ctDNA in patients with HLH, and see if it is possible to use it to diagnose lymphoma earlier. Patients will provide a small additional blood

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria: * Informed consent. * Age โ‰ฅ18 years. * Clinically confirmed HLH. * High dose steroids and/or systemic anti-cancer therapy (SACT) for \<72 hours for the current episode of HLH (anakinra is not considered SACT). Prior steroid use \>14 days at the time of consent is permitted. * Patients with recurrent HLH may be included. * Patients already known to have underlying lymphoma, or have relapsed lymphoma may be included. Exclusion criteria: โ€ข Cause of HLH already known to be due to a non-malignant cause.
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What it tests

  • Not listed
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Where

1 site
Nottingham Univeristy Hospitals NHS Trust
Nottingham, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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