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Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

RecruitingPhase 4Ages 40 Years - anyAllCentral Denmark Region
NCT05703919 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients over the age of 40 * EMT or Paramedic suspected AECOPD * Confirmed suspicion of COPD Exclusion Criteria: * Bronchospasm due to asthma, allergic reaction or non-COPD conditions * Known or suspected pregnancy * Prehospital Non-invasive, invasive or assisted bag mask ventilation * Allergy to inhaled bronchodilators (Salbutamol) * Inter-hospital transfer * More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated * Suspicion of acute coronary syndrome
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What it tests

  • Titrated Oxygen
  • Standard Oxygen
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Where

1 site
Prehospital Emergency Medical Servises, Central Denmark Region
Aarhus N, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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