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Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

RecruitingNAAges 18 Years - 100 YearsAllWest Virginia University
NCT05705999 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Diagnosis of Tourette Syndrome * Moderate Tic Severity at baseline Exclusion Criteria: * Presence of metallic objects or neurostimulators in the brain * Pregnancy * History of active seizures or epilepsy * Contraindications to receiving fMRI * Inability to participate in CBIT due to other underlying cognitive or medical condition
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What it tests

  • transcranial magnetic stimulation
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Where

1 site
WVU RNI
Morgantown, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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