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Exercise Therapy for Recurrent Low Back Pain: Unraveling the Puzzle of Peripheral Muscle and Central Brain Changes (B670201420984)

RecruitingNAAges 18 Years - 45 YearsAllUniversity Ghent
NCT05706103 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Exercise therapy has been shown to be effective in decreasing pain and improving function for patients with recurrent low back pain (LBP). Research on the mechanisms that trigger and/or underlie the effects of exercise therapy on LBP problems is of critical importance for the prevention of recurring or persistence of this costly and common condition. One factor that seems to be crucial within this context is the dysfunction of the back muscles. Recent pioneering results have shown that individuals with recurring episodes of LBP have specific dysfunctions of these muscles (peripheral changes) and also dysfunctions at the cortical level (central changes). This work provides the foundation to take a fresh look at the interplay between peripheral and central aspects, and its potential involvement in exercise therapy. The current project will draw on this opportunity to address the following

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📋 Eligibility rules (as published)
Inclusion Criteria: * History of non-specific recurrent LBP with the first onset being at least 6 months ago * At least 2 episodes of LBP/year, with an 'episode' implying pain lasting a minimum of 24 hours which is preceded and followed by at least 1 month without LBP * Minimum LBP intensity during episodes should be ≥2/10 on a numeric rating scale (NRS) from 0 to 10 * During remission the NRS intensity for LBP should be 0. * LBP should be of that severity that it limits activities of daily living * LBP should be of that severity that a (para)medic has been consulted at least once regarding the complaints * Flexion pattern of LBP Exclusion Criteria: * Chronic LBP (i.e. duration remission \<1 month) * Subacute LBP (i.e. first onset between 3 and 6 months ago) * Acute (i.e. first onset \<3 months ago) LBP * Specific LBP (i.e. LBP proportionate to an identifiable pathology, e.g. lumbar radiculopathy) * Patients with neuropathic pain * Patients with chronic widespread pain as defined by the criteria of the 1990 ACR (i.e. fibromyalgia) * A lifetime history of spinal traumata (e.g. whiplash), surgery (e.g. laminectomy) or deformations (e.g. scoliosis) * A lifetime history of respiratory, metabolic, neurologic, cardiovascular, inflammatory, orthopedic or rheumatologic diseases * Concomitant therapies (i.e. rehabilitation, alternative medicine or therapies) * Contra-indications for MRI (e.g. suffering from claustrophobia, the presence of metallic foreign material in the body, BMI \>30kg/m²) * Professional athletes * Pregnant women * Breastfeeding women * Women given birth in the last year before enrolment
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What it tests

  • Specific skilled motor training
  • General extension training
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Where

1 site
Ghent University, vakgroep revalidatiewetenschappen
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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